The Jacksonville Community Council Inc. developed the first community-based quality-of-life indicators assessment in the country in 1985.

Initiated in 1998 by The Center for Community Solutions and United Way of Greater Cleveland, the Social Indicators Project includes a six-volume series of reports outlining the social and health trends of the eight-county Northeast Ohio area.

Alameda County, California experiences severe disparities in health outcomes and related disparities in education, poverty level, and housing. The depth of these disparities was first documented in the Alameda County Health Status Report (CHSR) 2000, and reiterated in the subsequent 2003 and 2006 Status Reports. Data from the CHSRs have sparked debate among residents and policy makers, and guided the Alameda County Public Health Department leadership to accelerate conversations about broadening the department's efforts to work more closely with community partners to address the social conditions that create health inequities. Funding for this report was provided by Public Health Foundation.

In King County, Washington, the Community Counts Partnership led a community-driven process to select health indicators that reflect the social determinants affecting community members

In Western New York State's Monroe County, like in other New York counties, the rate of childhood lead poisoning was alarming, especially among low-income children. In response, the Coalition to Prevent Childhood Lead Poisoning was established in 2000 with a mission to "end childhood lead poisoning in Monroe County in 2010". Recognized by then-U.S. Senator Hilary Rodham Clinton as a "national model" for reducing childhood lead poisoning, the county coalition's efforts have cut childhood lead poisoning rates by 72% in eight years.

African Americans in Louisville, Kentucky, as in the rest of the U.S., experience greater health inequities compared to other racial and ethnic groups. This population, in particular, disproportionately experiences illness, violence-related injuries and premature death. In response, the Louisville Metro Department of Public Health and Wellness's Center for Health Equity is tracing the pathway from illness and injury to the community conditions, norms and root factors that lead to poor health and inequity in the first place. By building capacity among historically disenfranchised neighborhoods, CHE is leading an urban movement to promote equal opportunities for health and safety.

In the Upper Falls community of Rochester, New York, a dynamic collaborative of community members increases access to healthy food by organizing for over five years to bring a full-service supermarket into a community which lacked a single grocery store.

Working to reduce violence and crime in South Los Angeles, California, this community-driven, grassroots effort organizes community residents to close neighborhood liquor stores that negatively impact community health and safety.

The community-centered Fruitvale Transit Village Project connects the local transit station with the surrounding community of Fruitvale, a low-income, predominantly minority community in Oakland, California.

In Alameda County, California, The Senior Injury Prevention Partnership promotes a multi-factorial fall-prevention program that includes: physical activity, home safety, education, and medication management.